Development of Antimetastatic Drugs by Targeting Tumor Sialic Acids
نویسندگان
چکیده
منابع مشابه
Development of Antimetastatic Drugs by Targeting Tumor Sialic Acids
One-third of all cancer categories in clinics have a high incidence of neoplasm metastasis. Neoplasm metastasis is one of the leading causes of cancer deaths. However, the prevailing therapeutic approach to this pathogenic process is presently unsatisfactory. Paradoxically to our efforts and expectations, except for some antibodies, no obvious improvements and therapeutic benefits in currently ...
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Sialic acids are electronegatively charged C9-sugars and are considered to play important roles in higher animals and some microorganisms. Denoting their significance, understanding and exploiting the complexity of the sialic acids has been referred to as the "the third language of life". In essence, "sialic acid derivatives possess a harmonious shape and good balance between two opposing hydro...
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Recent reports from this laboratory (2-4) and other laboratories (5, 6) have elucidated the pathway of biosynthesis of N-acetylneuraminic acid from N-acetyl-n-mannosamine and phosphoenolpyruvic acid in mammalian systems. The over-all biosynthetic reaction for rat liver and bovine submaxillary gland is catalyzed by 3 enzymes: a kinase, a condensing enzyme, and a dephosphorylating enzyme. N-Acety...
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The skeletal system, comprising bones, ligaments, cartilage and their connective tissues, is critical for the structure and support of the body. Diseases that affect the skeletal system can be difficult to treat, mainly because of the avascular cartilage region. Targeting drugs to the site of action can not only increase efficacy but also reduce toxicity. Bone-targeting drugs are designed with ...
متن کاملTerminology for sialic acids.
We write on behalf of the Nomenclature Committee of the International Union of Biochemistry to comment on the proposal by Scott et al. (1982) to change the name of neuraminic acid to amino-sialosonic acid as a consequence of allotting the name sialose to a hypothetical 3-deoxynonulose. They further propose symbolizing sialose as Sia, sialosonic acid as SiaA, and aminosialosonic acid as SiaNA. W...
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ژورنال
عنوان ژورنال: Scientia Pharmaceutica
سال: 2012
ISSN: 0036-8709,2218-0532
DOI: 10.3797/scipharm.1205-01